Napoli continued their fine start to the season to defeat Salernitana 3-1 and move into the quarterfinals of the Coppa Italia.
The Campania club, who sit third in Serie A, were two up before the break after an own goal by Maurizio Peccarisi and Joao Inacio Pia's strike.
Arturo Di Napoli gave the Serie C1/B club brief hope with a goal five minutes after half-time, but just three minutes later a Marek Hamsik penalty sealed Napoli's progression.
Udinese needed penalties to eventually see of the top flight's bottom side Reggina, as they triumphed 8-7 on spot-kicks after a goalless clash.
Serie A strugglers Sampdoria were made to work hard by Empoli before progressing with a 2-1 victory at Stadio Luigi Ferraris.
Emiliano Bonazzoli's goal handed the Genoa club the lead and Bruno Fornaroli doubled the advantage from the spot on the stroke of half-time.
Francesco Lodi gave the Serie B side hope with half an hour remaining but they could not find an equalizer.