Columbus will clinch a berth in the Audi 2021 MLS Cup Playoffs IF:
- Columbus win vs. Chicago AND
- New York lose vs. Nashville AND
- Montréal lose or tie vs. Orlando AND
- D.C. lose or tie vs. Toronto AND
- Columbus win goal differential vs. New York
Columbus will clinch a berth in the Audi 2021 MLS Cup Playoffs IF: